Vit D Elisa 192T

Introduction Vit D Elisa 192T

Vit D Elisa 192T

Application of Vit D Elisa 192T kit

Vitamin D (OH)25 kit is designed for quantitative measurement of 25-hydroxyvitamin D in serum or plasma. This kit is supplied in a package of 192 tests by Arghvan Teb Kavian Company. Vitamin D is a fat-soluble vitamin that is responsible for maintaining and providing calcium and phosphorus in the blood by enhancing their absorption from food in the intestine and enhancing their reabsorption in the kidney.

Maintaining the proper concentration of calcium and phosphorus in the blood is necessary to strengthen bone formation and provide the proper concentration of calcium and phosphorus in the bones in order to make the bones stronger. In humans, the two main forms of vitamin D are vitamin D3 cholecalciferol and vitamin D2 ergocalciferol.

Vitamin D also refers to the hydroxylated metabolites of these two substances. Vitamin D2 is provided by food sources. Since only fish and some seafood are rich in vitamin D2, most dietary vitamin D in industrialized societies comes from vitamin D-fortified foods such as milk, vegetable butter, soybean oil, and other plant-based edible oils. be made

Vitamin D3 is produced in the skin after exposure to sunlight, especially ultraviolet (UVB) B rays. In this process, 7-dehydroxycholesterol reacts with ultraviolet B rays and vitamin D3 or cholecalciferol is produced. Exposure to sunlight for 10 to 15 minutes daily and at least 2 times a week is enough to make the necessary amounts of vitamin D.

The melanin pigment in the skin acts like a light filter in the skin, so dark-skinned people need more time in the sun to make the same amount of vitamin D compared to light-skinned people.

Any vitamin D produced in the skin or consumed through food in the liver and kidney is converted into 25-hydroxyvitamin D and 1- and 25-dihydroxyvitamin D or calcitriol during two hydroxylation steps, respectively. 1 and 25-dihydroxyvitamin D is the physiologically active form of vitamin D.

Dihydroxyvitamin D has a short half-life (4 to 6 hours) and its amount in plasma is approximately one thousandth of 25-hydroxyvitamin D.

25-Hydroxy vitamin D has a long half-life (2 to 3 weeks), its measurement is less influenced by daily changes, sunlight and consumption of foods containing vitamin D, and clinical science experts and scientific associations, its measurement They have accepted vitamin D as a criterion for determining the health level of vitamin D. Deficiency of 25-hydroxyvitamin D following things such as insufficient consumption in food, avoiding sunlight, malabsorption, liver and kidney disorders, use of anticonvulsants, such as phenytoin and phenobarbital (due to increased liver metabolism of vitamin D and a number of hereditary metabolic disorders) It is observed.

Breastfed babies, vegetarians who do not consume milk and eggs, people with dark skin, and the elderly are groups at risk of vitamin D deficiency. Its deficiency causes a decrease in bone minerals and subsequent softening of bones.

This phenomenon leads to rickets in children and osteomalacia in adults. Vitamin D deficiency also causes osteoporosis. The message of vitamin D inside the cell is involved in apoptosis or programmed cell death (cell proliferation and differentiation), so its deficiency can be related to the occurrence of cancer in the colon, breast and pancreas.

Vitamin D deficiency increases the risk of high blood pressure (due to increased renin production) and heart attacks. Monocytes, macrophages and activated T and B lymphocytes have the ability to synthesize the active form of vitamin D due to the presence of alpha-1-hydroxylase enzyme, and their enzyme activity is not affected by the amount of blood calcium and parathyroid hormone, unlike the kidney enzyme.

Vitamin D plays a role in the prevention of autoimmune diseases such as MS and type I diabetes through its effect on regulatory T lymphocytes.

Technical Specifications Vit D Elisa 192T

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