Total PSA Elisa 192T

Introduction Total PSA Elisa 192T

Total PSA Elisa 192T

Application of Total PSA Elisa 192T kit

The ELISA PSA Kit of Arghvan Teb Kavian Company is designed for laboratory quantitative measurement of total prostate-specific antigen antigen (tPSA) in serum or plasma.

This kit is supplied in a package of 192 tests by Arghvan Teb Kavian. Prostate-specific antigen or PSA is a type of serine protease from the kallikrein family that is produced exclusively in the epithelial cells of the prostate gland. PSA production is under the regulation of male sex hormone receptors or androgens. Due to its high tissue specificity, PSA measurement has been the most widely used diagnostic tool.

Prostate-specific antigen is able to form a complex with endogenous protease inhibitors such as 1-antichymotrypsin (ACT), alpha-2-macroglobulin and alpha protease inhibitor (API), which is referred to as PSA or cPSA complex. . About 90% of cPSA is bound to ACT and is measured in the total PSA test, but its complex with alpha-2 macroglobulin cannot be measured by the usual total PSA test methods.

Only about 10-30% of total PSA is present in free form in serum, which, of course, lacks protease activity. Prostate cancer is one of the common problems of men, especially in old age. Various studies have shown the prevalence of prostate cancer in men between 70 and 79 years between 36 and 51 percent. Unfortunately, many of these cancers are silent, and only by testingTotal PSA assays and detailed clinical examinations are detectable.

In addition to prostate cancer, its rate increases in other cases such as benign prostatic hypertrophy (BPH) and inflammation of the prostate. Despite the increase in tPSA in cases other than prostate cancer, the value of its measurement has been proven to reduce the mortality of men by 20% in many previous long-term studies.

Also, today, other measures have been introduced to increase the specificity of the tPSA test and distinguish prostate cancer cases from other benign cases, including the calculation of the ratio of free PSA (fPSA) to total PSA (tPSA) in the normal range based on age. /fPSA) and the specific assay of PSA complex with ACT (PSA-ACT) indicated.

The reduction in tPSA is considered as a measure to monitor the success of treatment in men who have undergone radial prostatectomy surgery, chemotherapy, adjuvant therapy and radiation therapy. Since PSA exists in small amounts in the glands of the peripheral tissue of the urethra, anus, and cancerous breast tissue, therefore, PSA can be measured in women as well.

Sometimes the mentioned reason causes some PSA in the blood even after surgery and prostate removal. Cases such as urinary retention following rectal examination, or cystoscopy, colonoscopy, and intraurethral biopsy, laser therapy that leads to prostate inflammation or trauma, lead to a degree of tPSA increase that should always be taken into account in the interpretation of any result greater than the normal range.

Technical Specifications Total PSA Elisa 192T

User comments