T Uptake Elisa 96T

Introduction T Uptake Elisa 96T

T Uptake Elisa 96T

Application of T Uptake Elisa 96T kit

The uptake-T kit of Arghvan Teb Kavian Company is designed for quantitative measurement of free thyroxine hormone or 4T Free in serum or plasma. This kit is supplied in a package of 96 tests by Arghvan Teb Kavian Company. Two hormones thyroxine (T4) and triiodothyronine (T3) are produced by the thyroid gland and enter the blood.

Most of the T4 and T3 present in the blood are transported bound to the proteins TBG, transthyretin (formerly called prealbumin) and albumin, but the affinity of TBG to T3 is lower compared to T4, so compared to thyroxine, fraction There is more T3 in free form (0.3% of T3 compared to 0.02% of T4). However, due to the daily production of three times more T4 than T3, the absolute amount of free T4 is greater than free T3.

The biologically active part of thyroid hormones is the free part of these hormones. Some factors such as pregnancy or the use of oral contraceptive pills cause an increase in the concentration of binding proteins of thyroid hormones, and the thyroid gland increases the production of thyroid hormones through a compensatory mechanism in these cases until the amount of free hormone is in the constant range required for the vital activities of the body. to remain

In these cases, the concentration of total thyroid hormones increased, without any signs of hyperthyroidism or changes in TSH concentration. The thyroid hormone uptake test or uptake-T is a kind of indirect measurement of the unoccupied positions of plasma binding proteins and is designed for this purpose. Following the measurement of uptake-TThe free thyroxine index (FTI or Thyroxine Free Index) is obtained from the following equation:

FTI=

In this regard, Reference T-uptake is the T-uptake value of the laboratory index, which is obtained by averaging the T-uptake results of normal people. According to the T-uptake reference range, this value is often considered equal to 30 in this regard.

In hyperthyroidism and hypothyroidism, the amount of T-uptake and thyroxine increases or decreases in parallel with each other, but in abnormalities of binding proteins, the amount of these two changes in the opposite direction and following the increase of T-uptake, the amount of total thyroxine increases. decreases, or with a decrease in T-uptake, total thyroxine increases. For example, in pregnancy or taking oral contraceptive pills, an increase in the amount of total thyroxine is associated with a decrease in the amount of T-uptake.

Technical Specifications T Uptake Elisa 96T

User comments