PRL Elisa 96T

Introduction PRL Elisa 96T

PRL Elisa 96T

Application of PRL Elisa 96T kit

Kit ELISA Prolactin of Arghvan Teb Kavian Company is designed for laboratory quantitative measurement of prolactin hormone (Prolactin) in serum or plasma. This kit is supplied in a package of 96 tests by Arghvan Teb Kavian Company. Prolactin is produced in the anterior pituitary gland and secreted periodically. This hormone consists of 198 amino acids with an approximate molecular weight of 22 to 23 kilodaltons. Prolactin is found in serum in three forms.

The biologically active form of a single unit or monomer (little) which is the dominant form of prolactin in serum and makes up about 80% of serum prolactin. There are 5-20% in the biological inactive form of two units or dimer (big form) and 0.5-5% in the inactive four-unit tetramer form (very large or big-big) in the serum. The target organ of prolactin is the mammary gland, which stimulates its growth and differentiation. High concentrations of prolactin have an inhibitory effect on the production of steroids in the ovary and the production and secretion of pituitary gonadotropins. 

During pregnancy, the level of serum prolactin increases significantly due to the increase in estrogen and progesterone. One of the most common causes of infertility in men and women is increased prolactin levels. The stimulating action of prolactin on the mammary glands leads to breastfeeding after childbirth.

Measuring prolactin levels is used to diagnose female sexual cycle irregularities, amenorrhea due to increased prolactin, galactorrhea, breast enlargement, primary hypothyroidism, polycystic ovary, anorexia and sperm deficiency in men. Paraneoplastic tumors such as lung cancer can act as abnormal prolactin production centers and cause an increase in serum prolactin.

Usually, very high levels of prolactin indicate the presence of pituitary adenoma. Prolactin measurement is also used when breast cancer and pituitary tumors are suspected. Sometimes, the amount of large and very large forms of prolactin in the serum is increased and very high levels of prolactin are detected in immunoassay methods. This condition, referred to as macroprolactinemia, is not accompanied by significant clinical symptoms due to the inactivity of the large forms and must be distinguished from true hyperprolactinemia.

Technical Specifications PRL Elisa 96T

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