Free T4 Elisa 192T

Introduction Free T4 Elisa 192T

Free T4 Elisa 192T

Application of Free T4 Elisa 192T kit

Kit ELISA 4FT of Arghvan Teb Kavian Company is designed for quantitative measurement of free thyroxine hormone or Free T4 in serum or plasma. This kit is supplied in a package of 192 tests by Arghvan Teb Kavian. Two hormones thyroxine T4 and triiodothyronine T3 are produced by the thyroid gland and enter the blood. Only 20% of the T3 hormone is made directly by the thyroid, and 80% is made by the 5-iodinase enzyme in the tissue from removing an iodine atom from thyroxine.

Since the half-life of T3 is shorter compared to T4 (2 days compared to 7 days), thyroxine seems to act mainly as a storage source and precursor of T3, which is the most biologically active form of thyroid hormones. Most of the T4 and T3 present in the blood are transported bound to the proteins TBG, transthyretin (previously called prealbumin) and albumin, but the affinity of TBG to T3 is lower compared to T4, so compared to thyroxine, a larger fraction of T3 is present in free form (0.3% of T3 compared to 0.02% of T4). However, due to the daily production of three times more T4 than T3, the absolute amount of free T4 is greater than free T3.

The biologically active part of thyroid hormones is the free part of these hormones. The main stimulus for the production of thyroid hormones is the thyrotropin hormone or TSH secreted by the pituitary gland, which is under the control of the thyrotropin-releasing hormone (TRH) produced by the hypothalamus, both of which are under the control of T3 and T4. Thyroid hormones strengthen many intracellular actions and They promote cell growth and differentiation.

Thyroid hormones increase oxygen consumption and ATP production, mitochondrial metabolism, synthesis and metabolism of carbohydrates, synthesis and breakdown of cholesterol and triglycerides (for example, through the regulation of LDL receptor expression in the liver), tissue sensitivity to catecholamines. . It also increases heart rate and contractility of heart muscles. In addition to the mentioned cases, thyroid hormones play an important role in regulating the metabolism of calcium and phosphorus in the growth and development of fetuses and children.

The amount of T4 hormone increases in hyperthyroidism and decreases in hypothyroidism, which may be associated with a decrease or increase in TSH, respectively Factors such as pregnancy or the use of oral contraceptive pills and acute inflammatory liver diseases that increase the concentration of thyroid hormone binding proteins can increase the amount of total thyroid hormones in the serum, while the amount of free hormones in these people It is natural.

In these people, TSH is usually in the reference range. In the presence of factors that cause a change in the amount or tendency of binding proteins to thyroid hormones, and non-thyroid diseases (NTI), free hormone measurement is a better indicator compared to total hormone in evaluating thyroid function, especially in cases of hyperthyroidism.

Technical Specifications Free T4 Elisa 192T

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